… effects of genetic background on the skeletal phenotype of mice with type 2 cannabinoid
receptor deficiency … We studied Cnr2 −/− mice on a CD1 background and compared the findings …

… with targeted inactivation of the type 2 cannabinoid receptor (Cnr2 −/− ) … bone mass and
reduced osteoclastic bone resorption … The largest changes were in Cnr2 itself and the interleukin-…

… bone mass due to a defect in osteoclastic bone resorption, but … same genetic background
had normal peak bone mass and … The changes in bone mass and bone structure that occurred …

… Cannabinoid receptors CB1 and CB2 are expressed in bone and regulate … between the
effect of CB1 and CB2 activation reported using genetically modified animal models. Studies on …

… (type 2 cannabinoid receptor) is associated with maintaining … These changes are the
consequence of a continuous … Although the CB1 cannabinoid receptor has been identified in …

… receptors type 1 (CB1) and type 2 (CB2) (3); transient … no changes in biomechanical
characteristics of femoral bones of … , can influence the effects of cannabinoid receptor signaling on …

… of Cannabis sativa has been implicated in changes in bone … precursor cells by suppressing
cannabinoid receptor type 2. … We observed that genetic inactivation of CB1 receptors in …

… CB1 deficiency on a CD1 background had high bone mass … changes in nuclear morphology
using 4′,6-diamidino-2-… To minimize the chance of genetic drift, CB2 −/− mice used in …

… type 1 (CB1) and peripheral cannabinoid receptor type 2 (… These changes are reminiscent
of human osteoporosis and … gene encoding CB2 with postmenopausal osteoporosis (40). …

… on the action of the cannabinoid receptor ligands in skeleton … receptor type 2 (CB2R), which
were isolated and cloned only … in bone by modifying OB and OC differentiation and actions. …